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CHM.1003 - Acetic acid-d 99 atom%D - 758-12-3
Acetic acid-d (CD₃COOD), with 99 atom % deuterium (D), is a deuterated form of acetic acid where the hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This compound is primarily used in specialized scientific and industrial applications due to its unique isotopic properties. Below is an overview of its usage:
Usage of Acetic acid-d (99 atom % D)
  • Nuclear Magnetic Resonance (NMR) Spectroscopy:
    • Acetic acid-d is widely used as a solvent in NMR spectroscopy. Deuterated solvents like acetic acid-d are preferred because they produce minimal interference in the NMR spectrum, allowing for clearer analysis of the sample.
    • It is also used as an internal standard or reference compound in NMR experiments.
  • Deuterium Labeling in Chemical Synthesis:
    • Acetic acid-d is used as a reagent in the synthesis of deuterium-labeled compounds. These labeled compounds are important in:
      • Mechanistic studies: To trace reaction pathways and understand chemical mechanisms.
      • Metabolic studies: To study the metabolism of drugs and other compounds in biological systems.
      • Isotope effect studies: To investigate the kinetic and thermodynamic effects of replacing hydrogen with deuterium.
  • Pharmaceutical Research:
    • Deuterated compounds, including acetic acid-d, are used in the development of deuterated drugs. Deuterium substitution can alter the pharmacokinetics and metabolic stability of drugs, potentially improving their efficacy and safety.
  • Analytical Chemistry:
    • Acetic acid-d is used in mass spectrometry (MS) and other analytical techniques as a solvent or reagent to study deuterium incorporation or to prepare deuterated standards for calibration.
  • Material Science:
    • In the study of polymers and other materials, acetic acid-d can be used to investigate the effects of deuteration on material properties, such as molecular dynamics and structural stability.
  • Biochemical and Biological Research:
    • Acetic acid-d is used in studies involving protein structure, enzyme mechanisms, and metabolic pathways, where deuterium labeling provides insights into molecular interactions and dynamics.
Safety and Handling:
  • Chemical Stability: Acetic acid-d is chemically similar to regular acetic acid but has isotopic differences. Handle it in a well-ventilated area or fume hood to avoid inhalation or contact.
  • Corrosiveness: Like acetic acid, it is corrosive to skin and eyes. Use appropriate personal protective equipment (PPE), such as gloves and safety goggles.
  • Storage: Store in a tightly sealed container in a cool, dry place, away from incompatible materials (e.g., strong oxidizers).
  • Disposal: Follow local regulations for the disposal of deuterated compounds and organic acids.
Key Notes:
  • Acetic acid-d is a high-purity reagent, and its 99 atom % D content ensures minimal contamination from protiated (hydrogen-containing) species.
  • Always refer to the Material Safety Data Sheet (MSDS) for specific safety and handling guidelines.

CHM.1003 - Acetic acid-d 99 atom%D - 758-12-3

SKU: CHM.1003
€126.67Price
Quantity

  • Chemical Specifications of Acetic acid-d (99 atom % D)

    • Chemical Name:

      • Acetic acid-d (Deuterated acetic acid)

      • IUPAC Name: Deuterated ethanoic acid

    • Molecular Formula:

      • CD₃COOD

    • CAS Number:

      • 758-12-3

    • Molecular Weight:

      • 64.08 g/mol

    • Deuterium Content:

      • 99 atom % D (minimum)

    • Purity:

      • ≥ 99.5% (by NMR or GC)

    • Appearance:

      • Clear, colorless liquid

    • Odor:

      • Pungent, vinegar-like odor (similar to acetic acid)

    • Density:

      • ~1.12 g/cm³ at 25°C (slightly higher than non-deuterated acetic acid due to deuterium substitution)

    • Boiling Point:

      • ~118-119°C (slightly higher than non-deuterated acetic acid)

    • Melting Point:

      • ~16-17°C

    • Solubility:

      • Miscible with water, ethanol, and other polar solvents

    • Refractive Index:

      • ~1.372 at 20°C

    • pH:

      • ~2.4 (1% solution in water, similar to non-deuterated acetic acid)

    • Stability:

      • Stable under normal conditions, but may react with strong oxidizers, bases, and reactive metals.

    • Storage Conditions:

      • Store in a tightly sealed container at room temperature (15-25°C) in a cool, dry place.

      • Protect from moisture and light.

    • Hazard Information:

      • Corrosive to skin and eyes.

      • May cause respiratory irritation if inhaled.

      • Use appropriate PPE (gloves, goggles, lab coat) and handle in a fume hood.

    • NMR Solvent Properties:

      • Commonly used as a solvent in proton (¹H) NMR spectroscopy.

      • Residual proton signal (non-deuterated impurity): < 1% (typically around 0.05-0.1%).

    • Impurities:

      • Non-deuterated acetic acid (CH₃COOH): < 1%

      • Water (H₂O): < 0.1%

      • Other organic impurities: < 0.1%

    • Regulatory Information:

      • Complies with REACH and other relevant chemical regulations.

    Typical Applications:

    • NMR spectroscopy (solvent or reference compound)

    • Deuterium labeling in chemical synthesis

    • Pharmaceutical research (deuterated drug development)

    • Analytical chemistry (mass spectrometry, isotope studies)

    • Biochemical and metabolic research

    Notes:

    • The specifications provided are general and may vary depending on the supplier. Always refer to the Certificate of Analysis (CoA) provided by the manufacturer for batch-specific details.

    • Ensure proper handling, storage, and disposal in compliance with local regulations and safety guidelines.

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