TPTZ is a tridentate ligand with three pyridyl groups attached to a triazine core, making it highly effective in forming stable complexes with metal ions.
1. Key Applications
Coordination Chemistry
Metal Complexation: TPTZ is widely used to form stable complexes with transition metals (e.g., Fe²⁺, Cu²⁺, Zn²⁺) due to its strong chelating ability.
Catalysis: Metal-TPTZ complexes are employed as catalysts in various organic reactions, including oxidation and polymerization.
Analytical Chemistry
Colorimetric Assays: TPTZ is a key component in the Ferric Reducing Antioxidant Power (FRAP) assay, used to measure the antioxidant capacity of biological samples.
Iron Detection: Forms a colored complex with Fe²⁺, enabling the quantitative detection of iron in environmental and biological samples.
Materials Science
Luminescent Materials: Metal-TPTZ complexes are used in the development of luminescent materials for optoelectronic applications.
Coordination Polymers: TPTZ is used to synthesize coordination polymers and metal-organic frameworks (MOFs) with potential applications in gas storage and separation.
Biological and Medicinal Chemistry
Antioxidant Studies: Used in studies to evaluate the antioxidant properties of natural and synthetic compounds.
Metal Chelation Therapy: Investigated for its potential use in chelation therapy to remove excess metal ions from the body.
Electrochemistry
Redox-Active Ligand: TPTZ and its metal complexes are studied for their redox properties, making them useful in electrochemical sensors and energy storage devices.
Research and Development
Ligand Design: Used as a model ligand in the design and synthesis of new chelating agents with tailored properties.
Supramolecular Chemistry: Explored for its role in the assembly of supramolecular structures and host-guest complexes.
2. Industrial and Commercial Uses
Chemical Manufacturing: Used in the synthesis of catalysts and coordination compounds.
Pharmaceuticals: Employed in the development of antioxidant assays and metal chelation therapies.
Environmental Monitoring: Used in the detection and quantification of metal ions in water and soil samples.
Electronics: Investigated for use in luminescent materials and electrochemical devices.
3. Handling and Processing
Solubility: Soluble in organic solvents such as ethanol, methanol, and acetonitrile.
Storage: Should be stored in a cool, dry place, away from light and moisture.
Processing: Typically used in solution-phase reactions for complexation and analysis.
4. Environmental and Safety Considerations
Toxicity: Generally low toxicity, but proper handling procedures should be followed to avoid inhalation or skin contact.
Environmental Impact: Should be used and disposed of in accordance with local regulations to minimize environmental impact.
CHM.209142 - 2,4,6-Tris(2-pyridyl)-s-triazine (TPTZ) - ≥98% - CAS: 3682-35-7
1. General Information
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Chemical Name: 2,4,6-Tris(2-pyridyl)-s-triazine
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CAS Number: 3682-35-7
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Molecular Formula: C₁₈H₁₂N₆
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Molecular Weight: 312.33 g/mol
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Appearance: White to off-white crystalline powder
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Purity: ≥98%
2. Physical and Chemical Properties
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Melting Point: ~240–245°C
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Solubility:
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Soluble in organic solvents (e.g., ethanol, methanol, acetonitrile).
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Insoluble in water.
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Density: ~1.35 g/cm³
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Refractive Index: Not applicable (solid form).
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Stability: Stable under normal conditions but may degrade under strong light or in the presence of strong acids/bases.
3. Composition
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Active Ingredient: 2,4,6-Tris(2-pyridyl)-s-triazine (≥98%).
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Impurities:
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≤2% (may include trace amounts of unreacted starting materials, by-products, or moisture).
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4. Functional Properties
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Chelating Ability: Strong tridentate ligand capable of forming stable complexes with transition metal ions.
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Redox Activity: Exhibits redox-active behavior, making it useful in electrochemical applications.
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Luminescence: Metal-TPTZ complexes can exhibit luminescent properties.
5. Storage and Handling
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Storage Conditions:
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Store in a cool, dry place, away from light and moisture.
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Keep container tightly sealed to prevent contamination.
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Shelf Life: Typically 1–2 years when stored properly.
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