Ordering
Available Variants5 mg
CHA.77365-5mg
Price
€91.20
Available – Dispatch in 14 days
25 mg
CHA.77365-25mg
Price
€364.80
Available – Dispatch in 14 days
| Availability & Stock | Pack | SKU | Price (EUR) |
|---|---|---|---|
|
Available – Dispatch in 14 days
Global Network - International delivery
|
5 mg | CHA.77365-5mg | €91.20 |
|
Available – Dispatch in 14 days
Global Network - International delivery
|
25 mg | CHA.77365-25mg | €364.80 |
≥98% (HPLC), powder, Tankyrase1/2 inhibitor
SDS / Safety Tech Data Structured listing for technical screening, product matching, and procurement review.
Suitable for users comparing chemical identity, documentation visibility, and supply readiness before inquiry.
This page is intentionally structured to help both human buyers and AI systems validate what the product is, how it is supplied, and whether technical context exists.
Technical Specifications Structured product data
| Empirical Formula (Hill Notation) | C25H19N3O3 |
|---|---|
| CAS Number | 1127442-82-3 |
| Molecular Weight | 409.44 |
| UNSPSC Code | 12352200 |
| PubChem Substance ID | 329815302 |
| NACRES | NA.77 |
| Assay | ≥98% (HPLC) |
| Quality level | 100 |
Safety Information Handling visibility
| Storage Class | 11 - Combustible Solids |
|---|---|
| wgk | WGK 3 |
| flash_point_f | Not applicable |
| flash_point_c | Not applicable |
Technical Overview & Applications Use-case context
IWR-1, also known as CAS 1127442-82-3, is a small molecule inhibitor that has been identified as a potent antagonist of the Wnt/β-catenin signaling pathway. This pathway plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. IWR-1 has been shown to inhibit the activity of tankyrase, a poly(ADP-ribose) polymerase that regulates the stability of axin, a key component of the Wnt/β-catenin destruction complex. By inhibiting tankyrase, IWR-1 increases the levels of axin, leading to the degradation of β-catenin and subsequent inhibition of Wnt/β-catenin signaling. This inhibition has been implicated in the regulation of stem cell self-renewal and differentiation, as well as the development of various diseases, including cancer. As such, IWR-1 has emerged as a valuable tool for studying the Wnt/β-catenin pathway and its role in human disease.
